MTHFR is a test that can better help direct a person’s diet and optimize a supplement regiment. 

MTHFR (methylenetetrahydrofolate reductase) is the enzyme responsible for metabolizing folate to methyl folate which, in turn, is essential for converting homocysteine to methionine. Genetic variations in the MTHFR enzyme at the 677 and 1298 positions can affect this step and serum homocysteine levels. Homocysteine is a necessary amino acid that plays an important role in metabolism, but high levels are related to a higher risk of cardiovascular disease (CVD), especially stroke.

Moreover, when high levels of homocysteine are coupled with the MTHFR 677 T/T variant there is an even higher risk of stroke. Other MTHFR genotypes may also be associated with increased stroke risk.' Recent meta-analyses indicate clear associations of MTHFR genotypes 677 T/T, 677 C/T, 1298 A/C and 1298 C/C with increased risk of stroke. 

Individuals with the MTHFR 677 T/T genotype may require supplementation with methyl folate instead of folic acid to adequately lower their homocysteine levels. 

Lowering homocysteine in patients with either known cardiovascular disease or hypertension using either the combination of daily folic acid, vitamin B6, vitamin B12 per day has been shown to significantly reduce the risk of stroke.

Learn more about genetic testing.