How many APO E gene variations exist?

There are three APO E gene variations that occur naturally in humans: APO E 2, APO E 3, and APO E 4. Genes come in matching pairs, so we each have two copies of every gene (one from each parent). There are six possible combinations of APO E gene pairs or genotypes. If you received an APO E 2 from one parent and an APO E 3 from the other parent, the shorthand description of your genotype is E 2/3. The six possible combinations are E 2/2, E 2/3, E 3/3, E 4/2, E 4/3, and E 4/4.

What is the APO E gene?

APO is short for Apolipoprotein. It has the letter “E” because it’s one of a whole series of Apolipoproteins—A, B, C, D, etc. The APO E gene gets its name from the fact that it’s the blueprint in charge of synthesizing Apolipoprotein E, an important component of cholesterol and fat metabolism.

How is APO E pronounced?

APO E is pronounced by saying each letter separately: A - P - O - E.

Does everyone have an APO E genotype?

Yes. The question is, which type do you have?

Why is it important to know my APO E genotype?

Your APO E genotype greatly affects how your body processes carbohydrates, fats, and proteins, which in turn, affects your weight AND your predisposition toward certain chronic diseases, especially heart disease and Alzheimer's disease.

Once I know my APO E genotype, can anything be done to reduce my risk of getting these chronic illnesses?

Yes. By adopting a diet and lifestyle that is appropriate for your particular APO E genotype, you create a "Gene-Supportive Environment (GSE)" for your APO E genotype. Maintaining this GSE dramatically reduces your risk of developing chronic diseases such as heart disease and Alzheimer's disease.

Can the APO E Gene Online Program help me lose weight?

Yes. Following the dietary and lifestyle guidelines specific to your particular APO E genotype enables your body to more efficiently process carbohydrates, fats, and proteins. In essence, the APO E Gene Online Program creates a customized plan for your body to help you lose weight, while at the same time minimizing your risk of developing chronic diseases.

Is the APO E Gene Online Program the same for everyone?

No. That’s what so unique about this program. There are six APO E genotypes, and each genotype processes food in a unique way. Accordingly, there are specific optimal diet and exercise guidelines for each of the six APO E genotypes.

How do I find out what my APO E gene type is?

Learning your APO E genotype can be accomplished by performing a cheek swab test or a non-fasting blood test.

Can I get my APO E gene test at any lab?

No. The APO E gene test is a specialized test – not all labs perform this test.

Does my APO E gene test need to be ordered by a medical provider?

Yes. This test needs to be ordered by a licensed medical provider.

Do I need to fast for the APO E gene test?

No. Fasting is not required because we are only examining genetic material.

What should I consider before making the decision to be tested for my APO E genotype?

We strongly recommend reading The Perfect Gene Diet, by Pamela McDonald before making the decision to be tested. There are many factors to consider regarding gene testing, and this book will guide you through them. 

I want to be tested. How do I go about it?

Information on testing options can be found here.